Friday, February 26, 2010
Posted by Steve Murphy MD at 8:07 AM
Friday, February 19, 2010
I want to congratulate Dr Peter Hulick M.D. Medical Geneticist/Internist.
The afternoon program will additionally showcase:
· Four “prototypes of the future” sessions highlighting the next generation of personalized genomic products, services and activities and moderated by the executive editor of WIRED and author, Thomas "The Death Stare" Goetz.
· The public debut of the BioWeatherMap initiative, a collaboration between scientists and the public using next-generation sequencing platforms to address the fundamental question: “How diverse is the microbial life around us and how can we use that information to our advantage?”
The GET Conference 2010 will take place on Tuesday, April 27, 2010 from 8:00 a.m. – 8:00 p.m. at the Microsoft New England Research and Development Center in Cambridge, Mass. The event will be limited to 200 registrants. To register for the GET Conference 2010, visit http://www.getconference.eventbrite.com/.
Tommy Goetz hates me, but I still will go because, let's face it, who doesn't love the
"Howard Stern of Genomics"-Jeff Gulcher
The Sherpa Says: An army of geneticists amassing to deploy clinical useful tools in a virtual setting? Nawh.....
Posted by Steve Murphy MD at 6:18 AM
Thursday, February 18, 2010
Posted by Steve Murphy MD at 5:28 AM
Wednesday, February 17, 2010
"Are you FOR personalized medicine or not?"
"Nor should dated links that no longer apply to the fast evolving and current business/economic climate, technologies and law(s) in differing American States and the international sector be fused - adding to the confusion for neophytes...like me...who, though we are not of your august standing...deserve better from you.
"Is it your belief that ANY executive or Board Member who has a former affiliation is actually acting in the capacity of all former posts/affiliations/occupations"
"Are only physicians capable of avoiding conflicts of interests when they choose to participate in the business sector???"
No, no one is all that capable these days of avoiding conflicts of interests. That is why we declare them on CMEs we give, or in academic positions. It is this transparency that is needed. Do I own a DTC company? No. Do I make money from DTC testing? No. Would I make money off Genetic testing done in my office? No, not off the test.
"For those of us who are not physicians, bankers or biotech experts/lawyers...though your posts are always entertaining and provocative fun...confusing."
Posted by Steve Murphy MD at 5:05 AM
Tuesday, February 16, 2010
Wednesday, February 10, 2010
You know what pisses me off. The blatant stupidity given to hyping one piece of literature and making it seem as if it is true.
What pisses me off more is insinuating that there is some inherent value in a certain single study without prefacing the factors.
Let me tell you who often does that.
1. Nutriceutical salesmen in a Multi Level Marketing Scheme
2. People looking to sell some fancy medical device
3. Pharma companies creating fake journals
4. DTC Genomics companies trying to prove value from their tests......
Don't believe me? Well, just read the spittoon's blog post about TRALI....which is Transfusion Related Acute Lung Injury......
How does this hype occur? First the study....
It starts with a scare
"TRALI is one of the major causes of transfusion-association deaths in the developed world."-Spitton
Ok. We used to think this was rare and yes, it is more common based on some new agreed standards..... 1 in 300,000 people in some studies.....
Then it continues with baffling science jibberish to make people think you know what you are talking about........
"One reason TRALI happens is that ...... Several triggers for this type of TRALI have been identified. One of these, the HNA-3 antigen, has repeatedly been associated with severe and fatal TRALI reactions. HNA-3 comes in two versions: HNA-3a and HNA-3b........ The likelihood that a woman will have antibodies against HNA-3 increases with each birth.
The new research found that the different versions of HNA-3 are due to SNP rs2288904 in the SLC44A2 gene. Someone who is GG at this SNP will express only HNA-3a. Someone who is AG will express both the HNA-3a and HNA-3b version. Finally, someone who is AA at rs2288904 will express only HNA-3b. " -Spittoon
It finishes with a testimonial and a point of sale
"Confused? Here’s an example from my own family that will hopefully make things more clear:
What is wrong with this? It asserts that they would absolutely without a shadow of a doubt be at risk of TRALI........based on ONE STUDY!!!
And the point of sale?
"(23andMe Complete Edition customers can check their data for rs2288904 using the Browse Raw Data feature.)"
OMG, Holy Crap, I have to know whether I will be at risk for TRALI. Thank you so very much 23andMe! You have solved my life's problems. Maybe I could get a life alert bracelet with all of the "risks" I have?
Seriously. What would have been nice is a "This is only one study and there is no other replication out there, but, this is interesting EARLY SCIENCE"
We still have not conclusively implicated TRALI to just this.......There is no complete consensus on the absolute pathogenesis of TRALI.
Posted by Steve Murphy MD at 5:06 PM
Friday, February 5, 2010
When everyone poo poo'd Warfarin, I became very, very upset. Here was a good clinical case for using PGx tests. Not a great case, but a good case. It was only when I began to think about feasability.
Posted by Steve Murphy MD at 6:46 AM
Tuesday, February 2, 2010
By December 21st the writing was on the wall. It was pretty obvious CVS/Caremark had jumped over the number one PBM in the field MedCo.....
Well, the increased ownership in Generation Health that CVS/Caremark laid down was the way.....
The newest of the benefits management companies.....this time the focus was on genetic testing benefits.
Personally, this type of company should have been formed in 2005 when Insurers were hemorrhaging cash from those BRCA tests........
But, slow and deliberate do Insurers move....
On the 21st it of December it was all but decided for MedCo. Ummm, Ummmmm, who looks like this Generation Health company?????
I knew back then and now everyone knows today.
MedCo buys DNADirect.....
In 2005 when My Partner at the time Leslie Manace went out to "see" Ryan...... In what turned to be a huge probe of Leslie by Ryan, Ryan revealed......"We are interested in PGx" Which was funny because so were we. So much so that we really thought that this was the bees knees and in fact was likely the only useful and scalable testing to come out in the next 5 years.
The DTC Genomics companies were merely a twisted dream at the time.
Well, Ryan. Our hunch paid off.
By Diversifying your DTC genetic testing company into something useful such as a GBM, you have moved shrewdly. And when the PBM leader gets trumped by CVS, you reap the rewards.
I look forward to the first quarter report from MedCo to see exactly how much they acquired you for.
I have been saying on this blog that the answer for these DTC genomics companies is to follow your lead. Now the question is, which big insurer will now but a DTC genomics company?
For MedCo, I am a little disappointed that you decided to choose the exact type of company as Caremark did. There are lots of other solutions out there. I hope you still plan on increasing your footprint in this space. Because it would be bad if CVS/Caremark continues to gobble these companies up and you end up buying the second in class.....
Not that DNADirect is second in class, but Heather Shappell et.al. ARE First Class.......
The Sherpa Says: There has got to be a way to make these companies less reliant on people. Even in the genetics testing space, there is a way to automate.