You know what pisses me off. The blatant stupidity given to hyping one piece of literature and making it seem as if it is true.
What pisses me off more is insinuating that there is some inherent value in a certain single study without prefacing the factors.
Let me tell you who often does that.
1. Nutriceutical salesmen in a Multi Level Marketing Scheme
2. People looking to sell some fancy medical device
3. Pharma companies creating fake journals
4. DTC Genomics companies trying to prove value from their tests......
Don't believe me? Well, just read the spittoon's blog post about TRALI....which is Transfusion Related Acute Lung Injury......
How does this hype occur? First the study....
It starts with a scare
"TRALI is one of the major causes of transfusion-association deaths in the developed world."-Spitton
Ok. We used to think this was rare and yes, it is more common based on some new agreed standards..... 1 in 300,000 people in some studies.....
Then it continues with baffling science jibberish to make people think you know what you are talking about........
"One reason TRALI happens is that ...... Several triggers for this type of TRALI have been identified. One of these, the HNA-3 antigen, has repeatedly been associated with severe and fatal TRALI reactions. HNA-3 comes in two versions: HNA-3a and HNA-3b........ The likelihood that a woman will have antibodies against HNA-3 increases with each birth.
The new research found that the different versions of HNA-3 are due to SNP rs2288904 in the SLC44A2 gene. Someone who is GG at this SNP will express only HNA-3a. Someone who is AG will express both the HNA-3a and HNA-3b version. Finally, someone who is AA at rs2288904 will express only HNA-3b. " -Spittoon
It finishes with a testimonial and a point of sale
"Confused? Here’s an example from my own family that will hopefully make things more clear:
What is wrong with this? It asserts that they would absolutely without a shadow of a doubt be at risk of TRALI........based on ONE STUDY!!!
And the point of sale?
"(23andMe Complete Edition customers can check their data for rs2288904 using the Browse Raw Data feature.)"
OMG, Holy Crap, I have to know whether I will be at risk for TRALI. Thank you so very much 23andMe! You have solved my life's problems. Maybe I could get a life alert bracelet with all of the "risks" I have?
Seriously. What would have been nice is a "This is only one study and there is no other replication out there, but, this is interesting EARLY SCIENCE"
We still have not conclusively implicated TRALI to just this.......There is no complete consensus on the absolute pathogenesis of TRALI.