Friday, February 19, 2010

Hey! It's Pete Hulick! Are you Going to GET?

I want to congratulate Dr Peter Hulick M.D. Medical Geneticist/Internist.

I just read his wonderful article in the Internal Medicine News. For those who don't know Dr. Hulick, he is on heck of a doctor and a really nice guy. I look forward to more articles from him in the future!

Secondly, after all the big splash effort about the GET conference, I would like to encourage readers to attend.

“The GET Conference 2010 marks the last opportunity in history to gather a majority of individuals in the world with public personal genome sequences in a single venue,” says George Church, founder and principal investigator of the Personal Genome Project and professor of genetics at Harvard Medical School. “With rapid advances in technology, the number of individuals with personal genome sequences is expected to rise dramatically, from dozens today to thousands by 2011 and a million or more individuals within the next few years.”

That is a pretty heady statement by Dr. Church. Does he really think 2010 will be the year that 1000s of people will get whole genomes done?

I say, maybe a little hype. How about hundreds? Maybe....

The morning portion of GET Conference 2010 will feature wide-ranging discussions during which personal genome pioneers and globally recognized leaders of genomic science and industry, including the genetic bad-a$$ Misha Angrist, The O'l Man: George Church, Joltin Jay Flatley, "Do You Know Who I Am!" Henry Louis Gates, Jr., Rosalynn Gill, Seong-Jin Kim, Greg Lucier, James Lupski, Stephen Quake, Dan "Where's my refund?" Stoicescu and James "Well, It's True" Watson, will share their experiences and discuss the future of personal genomics. Award-winning science journalists Carl Zimmer and Robert Krulwich will moderate the discussions.

Why is this going to be a great conference? The speakers, that's why.

The afternoon program will additionally showcase:

· Four “prototypes of the future” sessions highlighting the next generation of personalized genomic products, services and activities and moderated by the executive editor of WIRED and author, Thomas "The Death Stare" Goetz.

· The public debut of the BioWeatherMap initiative, a collaboration between scientists and the public using next-generation sequencing platforms to address the fundamental question: “How diverse is the microbial life around us and how can we use that information to our advantage?”

The GET Conference 2010 will take place on Tuesday, April 27, 2010 from 8:00 a.m. – 8:00 p.m. at the Microsoft New England Research and Development Center in Cambridge, Mass. The event will be limited to 200 registrants. To register for the GET Conference 2010, visit

Tommy Goetz hates me, but I still will go because, let's face it, who doesn't love the

"Howard Stern of Genomics"-Jeff Gulcher

The Sherpa Says: An army of geneticists amassing to deploy clinical useful tools in a virtual setting? Nawh.....


Keith Robison said...

George is really on pretty solid ground predicting 1000+ genomes this year if you look around at the capacities both installed and planned.

There are somewhere between 20 and 30 human genomes either published in the literature or described at scientific conferences; perhaps 10-20 more done privately.

Complete Genomics (which George is connected to) has a stated goal of 5K genomes this year. While that might be ambitious, they have delivered genomes already which gives them some credibility.

Beijing Genome Institute has ordered 128 HiSeq instruments. Those will have a capacity of around 250 genomes/week (at factory specs, and not souped up in obvious ways). Not clear when they will have them all in house, but even if they had 5 in place by mid-year they could knock off 500 genomes. Not all that capacity may be on human either, obviously.

WashU has announced plans to sequence 150+ cancer genomes over the year; they have always in the past done normal controls. Some of those might be exomes.

Broad has similar capacity to WashU. Ditto Sanger. Various other commercial providers could easily generate 100 genomes (at least 3 commercial providers have announced HiSeq purchases). Combined output of all the core facilities and other genome centers could easily add a few hundred.

New Ignite Institute could have capacity in excess of 1000 genomes/year (100 SOLiD 4s -- I think they'll be about 0.5-1 genome per week).

PacBio instruments will start coming on line. They are potentially a genome a week or two, but perhaps in first incarnation not really cost effective or accurate for that.

Overall, I'd guess 99.99% chance of 100 genomes by end of year and 95+% of 1000. If you count exomes, it could push 5K-10K.

Andrew Y said...

If I come with you to GET 2010, will you come with me to Google I/O in SF in May?