This week in the American Journal of Psychiatry there is a study which links a specific haplotype(a few changes in the same copy of a gene) to ADHD onset. It is a confirmatory study(which is needed to draw any conclusions). The gene in question is the dopamine transporter DAT1. There has always been a familial risk of ADHD with identical twins being 70-90% likely to have the disease if their twin is afflicted. So naturally we have thought that this disease is primarily genetic. However, until lately the data did not indicate a significant role in DAT1 changes. But this literature is not very strong. Now there is a significant study, but this too needs some further investigation. Do I go out and get my kid tested for DAT1 polymorphisms? No. Does it give us hope for early identification of ADHD and other therapies besides a stimulant that stunts growth? You bet it does. Are there other ways to get ADHD without this gene change? You bet there are. That being said......
If there is a test and it is useful I will be the first to let you know.
Would you take the test?
Showing posts with label ritalin. Show all posts
Showing posts with label ritalin. Show all posts
Thursday, April 12, 2007
Skip the ritalin, get a genotype!!
Posted by
Steve Murphy MD
at
9:14 AM
2
comments
Labels: ADHD, DNA, DNA direct, dopamine transporter, genes, geneticist, genetics, germany, personalized medicine, ritalin
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