Go See a Gastro Doc

I am so blown away at the desperation (def: recklessness arising from despair) of the DTC companies. Recently my iPhone has been flooded with all sorts of clinically inaccurate information designed to make people think that something miraculously has changed with DTC genomics tests.

A change so impressive that it now appears as if you can actually do something about the results.

The best is a video now on Navi's website

2 sisters on the site taking about their results......likely plants......

The transcript includes these misleading words.......
Sister 1: We both tested "High" For Colon Cancer!

Sister 1: But the Crohn's disease was "really high" on my results. Which is interesting because, I didn't know we had that disease in our family......

Sister 2: It is a disease that is 75% genetic but 25% controllable by environment and diet

Sister 1: So I am making an appointment now to go see a "Gastro Doc"

Explain this to me, how in the hell are they getting away with such a flagrant use of insinuation that they tested for the exact 75% genetic part of Crohn's.... AND who the hell says it is 75% genetic but 25% controllable?

What does that exactly mean?

Chalk another piece of false advertising claims up to the geniuses at Navi......Good job Denise.

Let me know how that call with the FTC goes......and clean up your twitters.

Inferring that you can find out your risk for colon cancer with a gene test is false as well.... I am not going to even comment on their partnership with the Toronto Clinic other than to say that this will likely be the move of these companies prior to the US regulation hammer falling.....

They (DTC Genomics) will all move to foreign markets like Canada, Asia and maybe even Africa. Because the EU and likely the US will have had enough of their false claims and shenanigans.....

This video and the tests have tricked this ASYMPTOMATIC woman into going to see a specialist, for what I don't know....I can't wait to see the GI doctor's face. Assuming of course this wasn't just a bull$h!t marketing video that wasn't real.

The Sherpa Says: Want to know about Crohn's disease? Don't think that a few genes can give you disease or that we even know how to modify the environment enough to prevent it. I know for sure that eating some carrots, onions and peppers sure as hell ain't gonna prevent it.....I hate marketing lies. And these guys do it ALL the time.

New Crohn's Disease Genes Found

Big news in the world of IBD!

Crohn disease and ulcerative colitis represent the two common forms
of idiopathic inflammatory bowel disease (IBD), each with a prevalence
of roughly 100–150 per 100,000 individuals of European ancestry
This week in Nature Genetics a "genome-wide association study of Crohn disease
and two independent replication studies identify several new regions of association to Crohn disease."

This has been a disease that has multiple postulated causes. Some of the more modern include host-bacteria interaction leading to inflammation and disease. These associations implicate this as a possibility. More importantly they indicate risk of disease
The genes are in addition to CARD15(NOD2) and IL23R.

A coding variant in ATG16L1, the latter of which was also recently reported by another group is proven to be required for pathogenesis of Crohn's Disease. This gene is responsible for a process known as autophagy (required for our intrinsic immune system)

For non-scientsists/physicians

What does this mean? Well alot. If this is true, which it looks likely, then the next step is to clear the bowels(removing bacterium/Salmonella) of these persons with this polymoprhism. This would be another example of the possibility of personalized medicine.
Treatment based on predisposition. I am sure there are also pharma companies looking at halting ATG16L12's function with RNA intereference as demonstrated in this study!